Symbol
Name
ID

Was
Wiskott-Aldrich syndrome
MGI:105059

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Reduced natural killer cell activity

Increased circulating IgA level

Increased circulating IgE level

Decreased circulating total IgM

Decreased specific anti-polysaccharide antibody level

Abnormal delayed hypersensitivity skin test

Autoimmune hemolytic anemia

Eosinophilia

Neutropenia

Decreased CD4:CD8 ratio

Decreased proportion of CD4-positive helper T cells

Decreased proportion of CD8-positive T cells

Lymphopenia

Monocytopenia

Leukocytosis

Absent microvilli on the surface of peripheral blood lymphocytes

Impaired lymphocyte transformation with phytohemagglutinin

Recurrent sinusitis

Recurrent upper respiratory tract infections

Inflammation of the large intestine

Ulcerative colitis

Recurrent otitis media

Eczematoid dermatitis

Recurrent pneumonia

Reduced lymphocyte surface expression of CD43

Sepsis

Recurrent bacterial infections

Recurrent lower respiratory tract infections

Recurrent meningitis

Recurrent herpes

Disease(s) Associated with WAS

thrombocytopenia

Wiskott-Aldrich syndrome

X-linked severe congenital neutropenia

Mouse Phenotypes

immune system phenotype

abnormal osteoclast differentiation

abnormal B cell proliferation

decreased T cell proliferation

colitis

thymus hypoplasia

abnormal thymocyte activation

spleen hyperplasia

abnormal double-negative T cell morphology

abnormal double-positive T cell morphology

decreased double-positive T cell number

increased neutrophil cell number

abnormal mast cell morphology

abnormal B cell number

increased germinal center B cell number

decreased mature B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased follicular B cell number

increased plasma cell number

decreased B cell number

increased B cell number

decreased NK cell number

decreased T cell number

decreased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

abnormal dendritic cell morphology

abnormal lymphocyte morphology

increased splenocyte number

abnormal mast cell physiology

abnormal B cell physiology

increased IgA level

increased IgE level

increased IgM level

abnormal osteoclast physiology

lymphoid hypoplasia

abnormal dendritic cell physiology

abnormal dendritic cell antigen presentation

abnormal cytokine secretion

increased autoantibody level

increased anti-chromatin antibody level

increased anti-double stranded DNA antibody level

increased anti-single stranded DNA antibody level

glomerulonephritis

Availability

Mouse Genotype

Was^tm1Itl/Was^tm1Itl

Was^tm1Kas/Was^tm1Kas

Was^tm1Sbs/Was^tm1Sbs

Was^tm2Itl/Was^tm2Itl

Was^tm1Itl/Y

Was^tm1Sbs/Y

Was^tm2Itl/Y

Cd79a^tm1(cre)Reth/Cd79a⁺
Was^tm1.1Ldn/Was^tm1.1Ldn (conditional)

Cd79a^tm1(cre)Reth/Cd79a⁺
Was^tm1.1Ldn/Y (conditional)

Cd79a^tm1(cre)Reth/Cd79a⁺
Was^tm1.1Ldn/Was⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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